Physiological Circuit Properties

Circuit physiological properties

This sub-section examines the circuit-level physiology of the reconstructed microcircuit against relevant literature.

Several experimental protocols were replicated in silico to benchmark the network physiology of the reconstructed microcircuit. Properties that were evaluated include the frequency of network oscillations, laminar activity propagation, thalamocortical innervation, and excitation-inhibition balance.

The results of the consistency check were categorized as consistent, inconsistent, possibly consistent, not implemented or not applicable based on agreement with a given evaluation criterion.

	5 paper(s)
	0 paper(s)
	3 paper(s)
	28 paper(s)
	10 paper(s)

consistent - Randy M. Bruno and Bert Sakmann - Cortex is driven by weak but synchronously active thalamocortical synapses

consistent - Dirk Feldmeyer - Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex.

consistent - Michael S. Jones, Kurt D. MacDonald, Byung Ju Choi, F. Edward Dudek, and Daniel S. Barth - Intracellular correlates of fast (>200 Hz) electrical oscillations in rat somatosensory cortex.

consistent - Connors, BW - Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex.

consistent - Luhmann, HJ - Thalamic Network Oscillations Synchronize Ontogenetic Columns in the Newborn Rat Barrel Cortex.

not applicable - Callaway, E - Functional specialization of seven mouse visual cortical areas.

not applicable - Marcel Oberlaender - Simulation of signal flow in 3D reconstructions of an anatomically realistic neural network in rat vibrissal cortex.

not applicable - Roger D Traub - Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts.

not implemented - Connors, BW - A network of electrically coupled interneurons drives synchronized inhibition in neocortex.

not implemented - Korngreeen, B - Cellular and network contributions to excitability of layer 5 neocortical pyramidal neurons in the rat.

not implemented - Stuart, GJ - Cholinergic inhibition of neocortical pyramidal neurons.

not implemented - Stuart, GJ - Heterogeneity of phasic cholinergic signaling in neocortical neurons.

not implemented - Gordon M. G. Shepherd - Hierarchical connectivity and connection-specific dynamics in the corticospinal-corticostriatal microcircuit in mouse motor cortex.

not implemented - Solange P. Brown1 & Shaul Hestrin1 - Intracortical circuits of pyramidal neurons reflect their long-range axonal targets

not implemented - Masayuki Kobayashi - Postsynaptic Cell Type-Dependent Cholinergic Regulation of GABAergic Synaptic Transmission in Rat Insular Cortex

not implemented - Neil R. Hardingham - Presynaptic efficacy directs normalization of synaptic strength in layer 2/3 rat neocortex after paired activity.

not implemented - Gulledge, A - Selective serotonergic excitation of callosal projection neurons.

not implemented - Daniel E Shulz - Spike timing-dependent synaptic depression in the in vivo barrel cortex of the rat.

possibly consistent - Connors, BW - Abrupt maturation of a spike-synchronizing mechanism in neocortex.

possibly consistent - Alison L. Barth - An embedded subnetwork of highly active neurons in the neocortex.

possibly consistent - Luhmann, HJ - Carbachol-induced network oscillations in the intact cerebral cortex of the newborn rat.

possibly consistent - Medini, P. - Cell-type-specific sub- and suprathreshold receptive fields of layer 4 and layer 2/3 pyramids in rat primary visual cortex

possibly consistent - Korngreen, G - Cellular and network contributions to excitability of layer 5 neocortical pyramidal neurons in the rat.

possibly consistent - J. Julius Zhu - Chandelier cells control excessive cortical excitation: characteristics of whisker-evoked synaptic responses of layer 2/3 nonpyramidal and pyramidal neurons.

possibly consistent - Pinto, D - Circuit dynamics and coding strategies in rodent somatosensory cortex.

possibly consistent - Diego Contreras - Columnar interactions determine horizontal propagation of recurrent network activity in neocortex.

possibly consistent - Pinto, D - Cortical damping: analysis of thalamocortical response transformations in rodent barrel cortex.

possibly consistent - Stefano Panzeri - Decoding neuronal population activity in rat somatosensory cortex: role of columnar organization.

possibly consistent - Ikezoe, K. - Decorrelation of sensory-evoked neuronal responses in rat barrel cortex during postnatal development

possibly consistent - Alex Kwan - Dissection of cortical microcircuits by single-neuron stimulation in vivo.

possibly consistent - Thomas Klausberger, - Distinct firing patterns of identified basket and dendrite-targeting interneurons in the prefrontal cortex during hippocampal theta and local spindle oscillations.

possibly consistent - Paullus, J.R. - Diverse excitatory and inhibitory synaptic plasticity outcomes in complex horizontal circuits near a functional border of adult neocortex

possibly consistent - Yuri Zilberter - Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro.

possibly consistent - Scanziani, M - Gain control by layer six in cortical circuits of vision.

possibly consistent - Gordon M G Shepherd1,2,4, Armen Stepanyants2-4, Ingrid Bureau1,2, Dmitri Chklovskii2 & Karel Svoboda1,2 - Geometric and functional organization of cortical circuits.

possibly consistent - Keneth D Harris - Laminar structure of spontaneous and sensory-evoked population activity in auditory cortex.

possibly consistent - C. P. J. de Kock - Layer- and cell-type-specific suprathreshold stimulus representation in rat primary somatosensory cortex.

possibly consistent - Karim G. Oweiss - Millisecond-timescale local network coding in the rat primary somatosensory cortex.

possibly consistent - Mansvelder, H - Prelimbic and infralimbic prefrontal cortex interact during fast network oscillations

possibly consistent - Sakmann B - Reconstruction of an average cortical column in silico.

possibly consistent - Khazipov, R - Retinal waves trigger spindle bursts in the neonatal rat visual cortex.

possibly consistent - Jason Kerr - Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex.

possibly consistent - Contreras, D - Stimulus-dependent changes in spike threshold enhance feature selectivity in rat barrel cortex neurons.

possibly consistent - Stepanyants A - The fractions of short- and long-range connections in the visual cortex

possibly consistent - Steven J. Schiff - The role of inhibition in oscillatory wave dynamics in the cortex.

possibly consistent - Luhmann, HJ - Three patterns of oscillatory activity differentially synchronize developing neocortical networks in vivo.