Electrical properties

This sub-section assesses the properties of single neuron models in the reconstructed microcircuit against published literature.

The properties that were evaluated include ion channel kinetics, electrical firing patterns, passive properties like the resting membrane potential, membrane time constant, input resistance; active properties like AP amplitude, AP half width, firing frequency, inter-spike interval; dendritic properties like bAP and EPSP/IPSP attenuation.

The results of the consistency check were categorized as consistent, inconsistent, possibly consistent, input,not implemented or not applicable based on agreement with a given evaluation criterion.

paper(s)
paper(s)
paper(s)
paper(s)
paper(s)

consistent - Greg Stuart - Action potential initiation and propagation in rat neocortical pyramidal neurons. ext_link

input/validation/consistent
consistent
evaluation criterion
The action potential generation site in the pyramidal cell electrical models is in the AIS, and the dendrites show backpropagating APs
id
1
species
rat
age
P26-30
brain region
SSC
layer
L5
ME-Type
PC
aspect
action potentials
statement
Paper shows action potential generation in AIS, and bAP
pmid
9457640
title
Action potential initiation and propagation in rat neocortical pyramidal neurons.
contact Name
Greg Stuart
contributed by
Werner
checked by
WVG

consistent - Jochen F. Staiger - Functional diversity of layer IV spiny neurons in rat somatosensory cortex: quantitative morphology of electrophysiologically characterized and biocytin labeled cells. ext_link

input/validation/consistent
consistent
evaluation criterion
The electrical models for star pyramidal, spiny stellate and pyramidal cells show a regular firing pattern
id
2
species
rat
age
P19-21
brain region
Barrel cortex
layer
L4
ME-Type
L4 spiny neurons
aspect
L4 characterization
statement
Detailed morphological data characterizing three subpopulations of spiny neurons in slices of adolescent rats: (i) spiny stellate cells (58%), (ii) star pyramidal cells (25%) and (iii) pyramidal cells (17%)
pmid
15054049
title
Functional diversity of layer IV spiny neurons in rat somatosensory cortex: quantitative morphology of electrophysiologically characterized and biocytin labeled cells.
contact Name
Jochen F. Staiger
contributed by
Rajnish
checked by
WVG

consistent - Greg J. Stuart - Site of action potential initiation in layer 5 pyramidal neurons. ext_link

input/validation/consistent
consistent
evaluation criterion
The AP initiation in the pyramidal cell electrical models is between 30 to 60 mum from the soma
id
3
species
rat
age
P21-P35
brain region
SSC
layer
L5
ME-Type
PC
aspect
AP initiation
statement
AP initiation 35 microm from the axon hillock
pmid
16467534
title
Site of action potential initiation in layer 5 pyramidal neurons.
contact Name
Greg J. Stuart
contributed by
Werner
checked by
WVG

consistent - Rafael Yuste - State-dependent function of neocortical chandelier cells. ext_link

input/validation/consistent
consistent
evaluation criterion
ChC have an inhibitory function in the neocortical column model
id
4
species
mouse
age
P16-_25
brain region
neocortex
layer
-
ME-Type
ChC
aspect
Function of ChC cells
statement
We can compare role of BBP ChC with this paper.
pmid
22159102
title
State-dependent function of neocortical chandelier cells.
contact Name
Rafael Yuste
contributed by
rajnish
checked by
WVG

consistent - Bender KJ, Trussell LO. - The physiology of the axon initial segment. ext_link

input/validation/consistent
consistent
evaluation criterion
The electrical models have a separate AIS, with Na, K and Ca channels. The APs in the AIS are sharper than in the axon.
id
5
species
all
age
brain region
CNS
layer
ME-Type
aspect
ion channel compositions AIS
statement
review that describes which channels are present in the AIS
pmid
22443507
title
The physiology of the axon initial segment.
contact Name
Bender KJ, Trussell LO.
contributed by
Werner
checked by
WVG

inconsistent - Greg Stuart - Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. ext_link

input/validation/consistent
inconsistent
evaluation criterion
The electrical models of the pyramidal have a NaT density in the dendrites of ~200 pS/um2
id
6
species
rat
age
2 weeks
brain region
somatosensory cortex
layer
L5
ME-Type
PC
aspect
Electrophysiological properties
statement
apical Nat density = 40 pS/um2
pmid
8107777
title
Active propagation of somatic action potentials into neocortical pyramidal cell dendrites.
contact Name
Greg Stuart
contributed by
Etay Hay
checked by
WVG

input - Matthew Larkum - Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons. ext_link

input/validation/consistent
input
evaluation criterion
id
7
species
rat
age
4-8 weeks
brain region
somatosensory cortex
layer
L5
ME-Type
PC
aspect
Electrophysiological properties
statement
BAP attenuation
pmid
11389204
title
Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons.
contact Name
Matthew Larkum
contributed by
Etay Hay
checked by
WVG

input - Greg Stuart - Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. ext_link

input/validation/consistent
input
evaluation criterion
id
8
species
rat
age
3 weeks
brain region
somatosensory cortex
layer
L5
ME-Type
PC
aspect
Electrophysiological properties
statement
Ra = 100, voltage attenuation in apical dendrites and effect of Ih on attenuation
pmid
9570781
title
Determinants of voltage attenuation in neocortical pyramidal neuron dendrites.
contact Name
Greg Stuart
contributed by
Etay Hay
checked by
WVG

input - Henry Markram - Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex. ext_link

input/validation/consistent
input
evaluation criterion
id
9
species
rat
age
P13-16
brain region
somatosensory cortex
layer
L5
ME-Type
PC
aspect
Electrophysiological properties
statement
Firing features, Rin averages 50 Mohm, membrane time constant averages 20 ms
pmid
17124287
title
Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex.
contact Name
Henry Markram
contributed by
Etay Hay
checked by
WVG

input - Maarten Kole - Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output. ext_link

input/validation/consistent
input
evaluation criterion
id
10
species
rat
age
P28-70
brain region
somatosensory cortex
layer
L5
ME-Type
PC
aspect
Electrophysiological properties
statement
Eleak = -90 mV, Ih distribution
pmid
16467515
title
Single Ih channels in pyramidal neuron dendrites: properties, distribution, and impact on action potential output.
contact Name
Maarten Kole
contributed by
Etay Hay
checked by
WVG

not applicable - Donald G. Rainnie - A transcriptomic analysis of type I-III neurons in the bed nucleus of the stria terminalis. ext_link

input/validation/consistent
not applicable
evaluation criterion
This paper describes properties of BSTN neurons
id
11
species
rat
age
28-42 days old
brain region
BNST
layer
ME-Type
BNST(ALG) neurons
aspect
The intrinsic membrane currents Ih, IT and IK(IR) played a significant role in determining the subtypes of BNST neurons.
statement
This paper shows a Positive correlation between the physiological and genetic phenotype of BNST neurons : each distinct physiological cell types within the BNST shows a different pattern of Ion channel expression. These distinct genetic phenotypes can explain subtle differences in physiologic function.
pmid
21310239
title
A transcriptomic analysis of type I-III neurons in the bed nucleus of the stria terminalis.
contact Name
Donald G. Rainnie
contributed by
emmanuelle logette
checked by
WVG

not applicable - Donald G. Rainnie - A transcriptomic analysis of type I-III neurons in the bed nucleus of the stria terminalis. ext_link

input/validation/consistent
not applicable
evaluation criterion
BNST
id
12
species
rat
age
28-42 days old
brain region
BNST
layer
ME-Type
BNST(ALG) neurons
aspect
single-cell analysis of ion channel mRNA expression in the BNST neurons
statement
In this paper they showed that each different electrophysiologically identified subtypes of neurons in BNST expresses a characteristic profile of transcript for the 16 IC subunits studied.
pmid
21310239
title
A transcriptomic analysis of type I-III neurons in the bed nucleus of the stria terminalis.
contact Name
Donald G. Rainnie
contributed by
emmanuelle logette
checked by
WVG

not applicable - Stuart, GJ - Action potential initiation and propagation in layer 5 pyramidal neurons of the rat prefrontal cortex: absence of dopamine modulation. ext_link

input/validation/consistent
not applicable
evaluation criterion
This paper involves adult rat neurons, while the electrical models are for neurons of P14 rats. The electrical models also don't model calcium in the dendrites
id
13
species
rat
age
adult
brain region
pfC
layer
5
ME-Type
PC
aspect
AP initiation
statement
AP backpropagation in prefrontal layer 5 pyramidal neurons is robust but frequency dependent in the distal tuft, requires dendritic sodium rather than calcium channel activation, and, unlike other aspects of neuronal excitability, insensitive to modulation by dopamine
pmid
14673000
title
Action potential initiation and propagation in layer 5 pyramidal neurons of the rat prefrontal cortex: absence of dopamine modulation.
contact Name
Stuart, GJ
contributed by
SR
checked by
WVG

not applicable - Nedivi, E - Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex. ext_link

input/validation/consistent
not applicable
evaluation criterion
Area V1
id
14
species
mouse
age
adult
brain region
V1
layer
L2/3
ME-Type
PC
aspect
Spine dynamics
statement
Inhibitory synapses on dendritic shafts and spines differ in their distribution across the arbor and in their remodeling kinetics during normal and altered sensory experience.
pmid
22542188
title
Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex.
contact Name
Nedivi, E
contributed by
SR
checked by
WVG

not applicable - Larkman, A. - Correlations between morphology and electrophysiology of pyramidal neurons in slices of rat visual cortex. I. Establishment of cell classes. ext_link

input/validation/consistent
not applicable
evaluation criterion
Visual cortex
id
15
species
rat
age
brain region
visual cortex
layer
L2/3, L4,L5
ME-Type
PC
aspect
morphology, electrophysiology
statement
determine whether different classes of neocortical pyramidal neurons possess distinctive electrophysiological properties.
pmid
2332787
title
Correlations between morphology and electrophysiology of pyramidal neurons in slices of rat visual cortex. I. Establishment of cell classes.
contact Name
Larkman, A.
contributed by
Y. Shi
checked by
WVG

not applicable - Larkman, A. - Correlations between morphology and electrophysiology of pyramidal neurons in slices of rat visual cortex. II. Electrophysiology. ext_link

input/validation/consistent
not applicable
evaluation criterion
Visual cortex
id
16
species
rat
age
brain region
visual cortex
layer
L23.L5
ME-Type
PC
aspect
Electrophysiology
statement
Despite variation between individual cells of a single class, significant differences were found in the time constants, current/voltage relations, and repetitive firing behaviors of the 3 classes. Burst firing responses to injected current pulses were confined to the layer 5 cells with thick apical dendrites
pmid
2332788
title
Correlations between morphology and electrophysiology of pyramidal neurons in slices of rat visual cortex. II. Electrophysiology.
contact Name
Larkman, A.
contributed by
Y. Shi
checked by
WVG

not applicable - Hyong Kyu Kim - Dendritic localization and a cis-acting dendritic targeting element of Kv4.2 mRNA. ext_link

input/validation/consistent
not applicable
evaluation criterion
cultured rat hippocampal neurons
id
17
species
rat
age
1 day old pups
brain region
hippocampus
layer
ME-Type
cultured rat hippocampal neurons
aspect
regulation of Ion channel mRNA localisation
statement
In this paper, they identified the cis-acting element responsible for the dendritic localisation of kv4.2 mRNA. This targeting sequence is located in the 3'UTR-region of the gene as in most mRNAs destined for localization in dendrites.
pmid
21034530
title
Dendritic localization and a cis-acting dendritic targeting element of Kv4.2 mRNA.
contact Name
Hyong Kyu Kim
contributed by
emmanuelle logette
checked by
WVG

not applicable - Yang, C. R. - Electrophysiological and morphological properties of layers V-VI principal pyramidal cells in rat prefrontal cortex in vitro. ext_link

input/validation/consistent
not applicable
evaluation criterion
Prefrontal cortex
id
18
species
rat
age
brain region
prefrontal cortex
layer
L5,L6
ME-Type
PC
aspect
Electrophysiological and morphological properties
statement
 Four principal pyramidal cell types were identified and classified as regular spiking (RS) (19%), intrinsic bursting (IB) (64%), repetitive oscillatory bursting (ROB) (13%), and intermediate (IM) (4%) types. All PFC cells exhibited either subthreshold oscillation in membrane voltage or pacemaker-like rhythmic firing
pmid
8774458
title
Electrophysiological and morphological properties of layers V-VI principal pyramidal cells in rat prefrontal cortex in vitro.
contact Name
Yang, C. R.
contributed by
Y. Shi
checked by
WVG

not applicable - Yves Gioanni - Electrophysiological Properties of Pyramidal Neurons in the Rat Prefrontal Cortex: An In Vivo Intracellular Recording Study ext_link

input/validation/consistent
not applicable
evaluation criterion
This paper described neurons from the prefrontal cortex
id
19
species
rat
age
brain region
prefrontal cortex
layer
L2-6
ME-Type
PC
aspect
Electrical properties of PCs
statement
Gives numbers for the electrical properies - see table 1 of the paper
pmid
11734528
title
Electrophysiological Properties of Pyramidal Neurons in the Rat Prefrontal Cortex: An In Vivo Intracellular Recording Study
contact Name
Yves Gioanni
contributed by
Melissa
checked by
WVG

not applicable - A. Korngreen - Experimentally guided modelling of dendritic excitability in rat neocortical pyramidal neurones. ext_link

input/validation/consistent
not applicable
evaluation criterion
The data in this paper describes very adult neuron (P35-P45)
id
20
species
rat
age
P35 - P45
brain region
somatosensory cortex
layer
L5
ME-Type
Pyramidal neurons
aspect
Comparamental neuron model based on experimental data
statement
Values for 19 different parameters in Table 1
pmid
19171651
title
Experimentally guided modelling of dendritic excitability in rat neocortical pyramidal neurones.
contact Name
A. Korngreen
contributed by
Oli
checked by
WVG

not applicable - Kole, MHP - Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model. ext_link

input/validation/consistent
not applicable
evaluation criterion
This paper involves adult neurons, while the electrical models are for neurons of P14 rats.
id
21
species
rat
age
adult
brain region
S1
layer
L5
ME-Type
PC
aspect
Neuronal excitability
statement
A rapid loss of dendritic HCN1 channels in WAG/Rij cortex precedes seizure onset. Further, we identify that dendritic HCN1 channel loss plays a direct role in frequency-dependent amplification of backpropagating action potentials, and enhances high-frequency burst firing in L5 pyramidal neurons, suggesting that HCN1 loss facilitates the initiation and propagation of spontaneous generalized seizures
pmid
17095562
title
Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model.
contact Name
Kole, MHP
contributed by
SR
checked by
WVG

not applicable - Avoli M - Inhibitory potentials in neurons of the deep layers of the in vitro neocortical slice. ext_link

input/validation/consistent
not applicable
evaluation criterion
This paper involves adult rat neurons, while the electrical models are for neurons of P14 rats.
id
22
species
rat
age
adult
brain region
sensorimotor region
layer
L5 and L6
ME-Type
neocortical neurons
aspect
Focal extracellular stimulation-induced hyperpolarization can last up to 1000 ms and show two components: (1) the early one (peak latency 10-20 ms), is inverted by diffusion of Cl- into the cell; (2) the late one is diminished by augmenting [K+]o. The membrane conductance is increased throughout the stimulus-induced hyperpolarization, mainly during the first 10-60 ms.
statement
resting membrane potential (Vm) of -60 to-85 mV (70.6 ± 5.8, mean ± S.D., n = 31), an apparent input resistance ranging from 25 to 52 Mff2 (38.0 ± 9.2, n = 23). The amplitudes of the action potentials generated in response to synaptic stimulation or intracellular depolarizing pulse were 70-100 mV (81.3 ± 7.8, n = 29)
pmid
3011189
title
Inhibitory potentials in neurons of the deep layers of the in vitro neocortical slice.
contact Name
Avoli M
contributed by
Oli
checked by
WVG

not applicable - Gyorgy Buzsaki - Intrinsic circuit organization and theta-gamma oscillation dynamics in the entorhinal cortex of the rat. ext_link

input/validation/consistent
not applicable
evaluation criterion
Entorhinal cortex
id
23
species
rat
age
adult
brain region
entorhinal cortex
layer
L2 to L5
ME-Type
EC
aspect
Gamma and theta waves modulation on EC
statement
LFP waves modulation in theta and gama on EC in vivo
pmid
20720120
title
Intrinsic circuit organization and theta-gamma oscillation dynamics in the entorhinal cortex of the rat.
contact Name
Gyorgy Buzsaki
contributed by
MPG
checked by
WVG

not applicable - Stuart, G - Mechanisms and consequences of action potential burst firing in rat neocortical pyramidal neurons ext_link

input/validation/consistent
not applicable
evaluation criterion
This paper involves P21-P35 neurons, while the electrical models are for neurons of P14 rats. The electrical models also don't model calcium in the dendrites
id
24
species
rat
age
P21-P35
brain region
cortex
layer
L5
ME-Type
PC
aspect
Mechanisms underlying generation of action potential
statement
High frequency action potential (330-/+10 Hz) burst firing is abolished by the removal of Ca2+ or the addtion of a Ca2+ channel antagonist. Weakened action potential burst firing is abolished by the blockade of dendrite Na channels with TTx as did the local apical dendrite application of Ni2-. Apical dendritic depolarisation results in low frequency (157+26Hz) action potential burst firing in regular firing neurons. The intensity of action potential burst firing facilitated by dendritic depolarisation. Action potential amplitude decreases when measured somatically. Axonal recordings showed that each action potential in a burst is axonally initiated and that no decrement in the AP is apparent in the axon > 30 um from the soma.
pmid
10581316
title
Mechanisms and consequences of action potential burst firing in rat neocortical pyramidal neurons
contact Name
Stuart, G
contributed by
Melissa
checked by
WVG

not applicable - Povysheva N V - Parvalbumin-positive basket interneurons in monkey and rat prefrontal cortex. ext_link

input/validation/consistent
not applicable
evaluation criterion
Barrel cortex
id
25
species
rat, monkey
age
P56-135, 4-5y
brain region
somatosensory barrel cortex
layer
2,3
ME-Type
basket cells, pyramidal cells
aspect
morphology, neurochemical, electrical
statement
The different physiological properties of basket FS interneurons from monkey and rat PFC may further inform our understanding of the nature of the functional differences between species
pmid
18632882
title
Parvalbumin-positive basket interneurons in monkey and rat prefrontal cortex.
contact Name
Povysheva N V
contributed by
Monica Favre
checked by
WVG

not applicable - Jackie Schiller - Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study. ext_link

input/validation/consistent
not applicable
evaluation criterion
The cells shown in this paper have a much older age than P14
id
26
species
rat
age
P36-P53
brain region
neocortex
layer
L5
ME-Type
PC
aspect
basal dendrites
statement
pmid
17206140
title
Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study.
contact Name
Jackie Schiller
contributed by
Werner
checked by
WVG

not applicable - Povysheva N V - Properties of excitatory synaptic responses in fast-spiking interneurons and pyramidal cells from monkey and rat prefrontal cortex. ext_link

input/validation/consistent
not applicable
evaluation criterion
This is a comparison between data from monkeys and rats. We only model rat neurons.
id
27
species
rat, monkey
age
P19-p29, 3.5-6kg
brain region
prelimbic, dorsolateral prefrontal cortex
layer
2,3
ME-Type
fast spiking interneurons, pyramidal cels
aspect
physiological properties of miniature EPSPs (mEPSPs), unitary EPSPs (uEPSPs; in connected pairs or by minimal stimulation), and EPSPs evoked by electrical stimulation of the white matter (eEPSPs)
statement
Membrane properties were very similar in pyramidal cells from rat and monkey PFC, but in both species these properties were significantly different from those of FS interneurons. EPSPs were significantly larger and faster in FS interneurons than those recorded from pyramidal cells
pmid
16033926
title
Properties of excitatory synaptic responses in fast-spiking interneurons and pyramidal cells from monkey and rat prefrontal cortex.
contact Name
Povysheva N V
contributed by
Monica Favre
checked by
WVG

not applicable - Kasper, Ekkehard M. - Pyramidal neurons in layer 5 of the rat visual cortex. I. Correlation among cell morphology, intrinsic electrophysiological properties, and axon targets. ext_link

input/validation/consistent
not applicable
evaluation criterion
Visual cortex
id
28
species
rat
age
brain region
visual cortex
layer
L5
ME-Type
PC
aspect
Morphology
statement
Every cell studied that projected to the superior colliculus was of the bursting type and had a thick apical dendrite with a terminal tuft. Every cell in this study projecting to the opposite visual cortex was a "nonburster" and had a slender apical dendrite with fewer oblique branches that ended without a terminal tuft, usually in the upper part of layer 2/3
pmid
8144741
title
Pyramidal neurons in layer 5 of the rat visual cortex. I. Correlation among cell morphology, intrinsic electrophysiological properties, and axon targets.
contact Name
Kasper, Ekkehard M.
contributed by
Y. Shi
checked by
WVG

not applicable - Kasper, Ekkehard M. - Pyramidal neurons in layer 5 of the rat visual cortex. I. Correlation among cell morphology, intrinsic electrophysiological properties, and axon targets. ext_link

input/validation/consistent
not applicable
evaluation criterion
Visual cortex
id
29
species
rat
age
brain region
visual cortex
layer
L5
ME-Type
PC
aspect
Morphology
statement
Every cell studied that projected to the superior colliculus was of the bursting type and had a thick apical dendrite with a terminal tuft. Every cell in this study projecting to the opposite visual cortex was a "nonburster" and had a slender apical dendrite with fewer oblique branches that ended without a terminal tuft, usually in the upper part of layer 2/3
pmid
8144741
title
Pyramidal neurons in layer 5 of the rat visual cortex. I. Correlation among cell morphology, intrinsic electrophysiological properties, and axon targets.
contact Name
Kasper, Ekkehard M.
contributed by
Y. Shi
checked by
WVG

not applicable - Neil V Marrion - Rapid endocytosis provides restricted somatic expression of a K+ channel in central neurons. ext_link

input/validation/consistent
not applicable
evaluation criterion
These experiments are in hippocampal slices in culture
id
30
species
rat
age
embryo
brain region
hippocampus
layer
ME-Type
cultured rat embryonic hippocampal neurons
aspect
restricted somatic expression of KCa 2.1, 2.2, 2.3 channels in central neurons
statement
Identification of specific binding motifs being responsible for targeting to a particular subcellular location + role of intracellular transport proteins in soma localisation of KCa 2.1, 2.2 and 2.3 ion channels
pmid
19861491
title
Rapid endocytosis provides restricted somatic expression of a K+ channel in central neurons.
contact Name
Neil V Marrion
contributed by
Emmanuelle Logette
checked by
WVG

not applicable - Neil V Marrion - Somatic colocalization of rat SK1 and D class (Ca(v)1.2) L-type calcium channels in rat CA1 hippocampal pyramidal neurons. ext_link

input/validation/consistent
not applicable
evaluation criterion
These experiments are on hippocampal neurons
id
31
species
rat
age
10- to 13-d-old rat pups
brain region
hippocampus
layer
ME-Type
pyramidal neurons
aspect
statement
pmid
11588205
title
Somatic colocalization of rat SK1 and D class (Ca(v)1.2) L-type calcium channels in rat CA1 hippocampal pyramidal neurons.
contact Name
Neil V Marrion
contributed by
emmanuelle Logette
checked by
WVG

not applicable - D.-J. Rhie - Subtype-Specific Dendritic Ca2+ Dynamics of Inhibitory Interneurons in the Rat Visual Cortex ext_link

input/validation/consistent
not applicable
evaluation criterion
Area V1
id
32
species
rat
age
p21-27
brain region
V1
layer
L2/3
ME-Type
IN
aspect
amplitude of Ca+ currents triggered by somatic action potential
statement
FS cells showed only small Ca2+ transients with a similar amplitude in all measured dendritic arbors <=105 µm from the soma (n = 11 cells) (Fig. 5A). These Ca2+ transients increased with the number of somatic APs <=10 APs (20 Hz), LS cells exhibited larger bAP-evoked Ca2+ transients of similar amplitude along the dendritic tree up to ~120 µm from the soma, which increased linearly with the number of somatic APs, Peak amplitude of bAP-evoked dendritic Ca2+ transients in BS cells increased as distance from the soma increased (n = 32 cells) and reached a plateau at ~50-100 µm from the soma
pmid
20554844
title
Subtype-Specific Dendritic Ca2+ Dynamics of Inhibitory Interneurons in the Rat Visual Cortex
contact Name
D.-J. Rhie
contributed by
MR
checked by
WVG

not applicable - Andreas H Burkhalter - Three distinct families of GABAergic neurons in rat visual cortex. ext_link

input/validation/consistent
not applicable
evaluation criterion
Visual cortex
id
33
species
rat
age
na
brain region
visual cortex
layer
L1-6
ME-Type
interneurons
aspect
classification
statement
at least three separate families of GABAergic neuronsin rat area 17thatcan be identified by the expression of PV, CR and SOM. These cellsaccount for 84.9% of GABAergic neurons
pmid
9177765
title
Three distinct families of GABAergic neurons in rat visual cortex.
contact Name
Andreas H Burkhalter
contributed by
Dimitri Christodoulou
checked by
WVG

not applicable - Mel, BW - Translation-invariant orientation tuning in visual "complex" cells could derive from intradendritic computations. ext_link

input/validation/consistent
not applicable
evaluation criterion
Area V1
id
34
species
cat
age
brain region
V1
layer
L5
ME-Type
PC
aspect
Synaptic integration
statement
Our model provides a novel, experimentally testable hypothesis regarding the basis of orientation tuning in the complex cell population, and more generally underscores the potential importance of nonlinear intradendritic subunit processing in cortical neurophysiology.
pmid
9592109
title
Translation-invariant orientation tuning in visual "complex" cells could derive from intradendritic computations.
contact Name
Mel, BW
contributed by
SR
checked by
WVG

not applicable - Staiger JF, Petersen CC - Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex. ext_link

input/validation/consistent
not applicable
evaluation criterion
Barrel cortex
id
35
species
mouse
age
brain region
Barrel cortex
layer
L2/3
ME-Type
Neocortical GABAergic neurons
aspect
molecular, structural and electrophysiological features
statement
spontaneous activity of SOM neurons during quiet wakefulness provides a tonic inhibition to the distal dendrites of excitatory pyramidal neurons
pmid
22366760
title
Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex.
contact Name
Staiger JF, Petersen CC
contributed by
Mirjia Herzog
checked by
WVG

not applicable - Staiger JF - Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex. ext_link

input/validation/consistent
not applicable
evaluation criterion
Barrel cortex
id
36
species
mouse
age
brain region
Barrel cortex
layer
L2/3
ME-Type
Neocortical GABAergic neurons
aspect
molecular, structural and electrophysiological features
statement
spontaneous activity of SOM neurons during quiet wakefulness provides a tonic inhibition to the distal dendrites of excitatory pyramidal neurons
pmid
22366760
title
Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex.
contact Name
Staiger JF
contributed by
Mirjia Herzog
checked by
WVG

not implemented - Burkhalter, A - A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons. ext_link

input/validation/consistent
not implemented
evaluation criterion
The electrical neuron model do not explicitely contain Kv4.2, Kv4.3 and Kv1.4
id
37
species
rat
age
brain region
hippocampus and cortex
layer
ME-Type
PC
aspect
ICs regulate Intrinsic Excitability of Cortical Pyramidal Neurons
statement
Kv4.2, Kv4.3 and Kv1.4 all contribute to the generation of IA channels in mature cortical pyramidal (CP) neurons and that Kv4.2-, Kv4.3- and Kv1.4-encoded IA channels play distinct roles in regulating the intrinsic excitability and the firing properties of mature CP neurons.
pmid
22615428
title
A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons.
contact Name
Burkhalter, A
contributed by
Mirjia Herzog
checked by
WVG

not implemented - Korngreen, A - Characterization of voltage-gated Ca(2+) conductances in layer 5 neocortical pyramidal neurons from rats ext_link

input/validation/consistent
not implemented
evaluation criterion
We don't implement the 5 subtypes of Cav mentioned in this paper
id
38
species
rat
age
p12-p16
brain region
S1
layer
5
ME-Type
TTL5
aspect
Ca2+ channels
statement
Contribution of the five Ca2+ channel sub-types to Ca2+ current flow during activation under physiological conditions
pmid
19337371
title
Characterization of voltage-gated Ca(2+) conductances in layer 5 neocortical pyramidal neurons from rats
contact Name
Korngreen, A
contributed by
SR
checked by
WVG

not implemented - Hanganu IL, Staiger JF, Ben-Ari Y, Khazipov R. - Cholinergic modulation of spindle bursts in the neonatal rat visual cortex in vivo. ext_link

input/validation/consistent
not implemented
evaluation criterion
Cholinergic innervation is currently not implemented
id
39
species
rat
age
5 and 6
brain region
Visual cortex
layer
ME-Type
neurons
aspect
modulation of spinal bursts
statement
cholinergic input facilitates the neonatal V1 spindle bursts and may prime the developing cortex to operate specifically on relevant early (retinal waves) and later (visual input) stimuli.
pmid
17522314
title
Cholinergic modulation of spindle bursts in the neonatal rat visual cortex in vivo.
contact Name
Hanganu IL, Staiger JF, Ben-Ari Y, Khazipov R.
contributed by
Mirjia Herzog
checked by
WVG

not implemented - Yuri Zilberter - Critical state of energy metabolism in brain slices: the principal role of oxygen delivery and energy substrates in shaping neuronal activity. ext_link

input/validation/consistent
not implemented
evaluation criterion
The electrical models don't mechanism the measure the energy metabolism of the neurons
id
40
species
rat
age
P19-44
brain region
hippocampus
layer
NA
ME-Type
aspect
Metabolism & neuronal activity
statement
energy metabolism determines the functional state of neuronal network, highlighting the need for the adequate metabolic support to be insured in the in vitro experiments
pmid
22232599
title
Critical state of energy metabolism in brain slices: the principal role of oxygen delivery and energy substrates in shaping neuronal activity.
contact Name
Yuri Zilberter
contributed by
J. Ryge
checked by
WVG

not implemented - Hyong Kyu Kim - Dendritic localization and a cis-acting dendritic targeting element of Kv4.2 mRNA. ext_link

input/validation/consistent
not implemented
evaluation criterion
The electrical neuron models do not explicitely contain Kv4.2 yet
id
41
species
rat
age
1 day old pups
brain region
hippocampus
layer
ME-Type
cultured rat hippocampal neurons
aspect
Ion channel mRNA localisation
statement
these results suggest that the dendritic localization of Kv4.2 mRNAs might regulate the dendritic surface level of Kv4.2 channels and synaptic plasticity. Also the subsequent translation of kv4.2 mRNA might be finely regulated by synaptic activity.
pmid
21034530
title
Dendritic localization and a cis-acting dendritic targeting element of Kv4.2 mRNA.
contact Name
Hyong Kyu Kim
contributed by
emmanuelle logette
checked by
WVG

not implemented - Waters, J - Effect of temperature on spiking patterns of neocortical layer 2/3 and layer 6 pyramidal neurons. ext_link

input/validation/consistent
not implemented
evaluation criterion
The ion channel kinetics we use are for a fixed temperature. We can not test the firing pattern at different temperatures
id
42
species
mouse
age
adult
brain region
S1/M1
layer
L2/3, 6
ME-Type
PC
aspect
Propagation of spiking activity in networks of excitatory and inhibitory neurons
statement
A decrease in spiking regularity with decreasing temperature, probably mediated by increased electrical coupling between soma and dendrites, is common to all pyramidal neurons in motor cortex.
pmid
22593736
title
Effect of temperature on spiking patterns of neocortical layer 2/3 and layer 6 pyramidal neurons.
contact Name
Waters, J
contributed by
SR
checked by
WVG

not implemented - Jeffrey Loeb - Electrical, molecular and behavioral effects of interictal spiking in the rat ext_link

input/validation/consistent
not implemented
evaluation criterion
The neocortical column model does not model epileptic behavior
id
43
species
rat
age
4 months old
brain region
somatosensory cortex
layer
2,3
ME-Type
aspect
development of interictal epileptic spiking
statement
interictal and ictal activities utilize distinct molecular pathways
pmid
22472188
title
Electrical, molecular and behavioral effects of interictal spiking in the rat
contact Name
Jeffrey Loeb
contributed by
John Fielden
checked by
WVG

not implemented - Schiller, J - Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons. ext_link

input/validation/consistent
not implemented
evaluation criterion
There are no NMDA spikes in the models
id
44
species
rat
age
p20-p40
brain region
S1
layer
L5
ME-Type
PC
aspect
Synaptic integration
statement
NMDA spikes in turn reliably trigger output bursts under in vivo-like stimulus conditions. Through their unique biophysical properties, NMDA spikes are thus ideally suited to promote the propagation of bursts through the cortical network.
pmid
19776275
title
Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons.
contact Name
Schiller, J
contributed by
SR
checked by
WVG

not implemented - Kole, MHP - First node of Ranvier facilitates high-frequency burst encoding. ext_link

input/validation/consistent
not implemented
evaluation criterion
The electrical models don't contain Nodes of Ranvier
id
45
species
rat
age
adult
brain region
S1
layer
L5
ME-Type
PC
aspect
Node of Ranvier & AP propagation
statement
nodal persistent Na+ current exerts an anterograde influence on AP initiation in the axon initial segment, revealing a computational role of the first node of Ranvier beyond conduction of the propagating AP.
pmid
21867883
title
First node of Ranvier facilitates high-frequency burst encoding.
contact Name
Kole, MHP
contributed by
SR
checked by
WVG

not implemented - Chen, Gu - Function and mechanism of axonal targeting of voltage-sensitive potassium channels. ext_link

input/validation/consistent
not implemented
evaluation criterion
Our electric models mostly contain pharmacolliogically specified current, this review mostly talks about genetically specified channels
id
46
species
Rat
age
adult
brain region
CNS
layer
ME-Type
aspect
statement
this review highlights recent studies that demonstrate different roles of axonal K+ channels in the local regulation of axonal excitability
pmid
21530607
title
Function and mechanism of axonal targeting of voltage-sensitive potassium channels.
contact Name
Chen, Gu
contributed by
Emmanuelle Logette
checked by
WVG

not implemented - Adam G Carter - GABAB receptor modulation of voltage-sensitive calcium channels in spines and dendrites. ext_link

input/validation/consistent
not implemented
evaluation criterion
There are no calcium dynamics implemented in the dendrites of our models
id
47
species
mouse
age
P21-28
brain region
medial prefrontal cortex
layer
L2/3
ME-Type
pyramidal neurons
aspect
dendritic currents
statement
we examine how GABABRs modulate Ca2+ signals evoked by action potentials (APs) in spines and dendrites of layer 2/3 pyramidal neurons in mouse prefrontal cortex.
pmid
21411663
title
GABAB receptor modulation of voltage-sensitive calcium channels in spines and dendrites.
contact Name
Adam G Carter
contributed by
Shruti
checked by
WVG

not implemented - Avanzini, G - Ionic mechanisms underlying burst firing in pyramidal neurons: intracellular study in rat sensorimotor cortex ext_link

input/validation/consistent
not implemented
evaluation criterion
The electrical models do not burst, there is no calcium in the dendrites
id
48
species
rat
age
brain region
sensorimotor region
layer
L5
ME-Type
PC
aspect
Ca2+ burst generation
statement
Block IAR with Ca2+ extracellular - does not affect burst generation
pmid
8574660
title
Ionic mechanisms underlying burst firing in pyramidal neurons: intracellular study in rat sensorimotor cortex
contact Name
Avanzini, G
contributed by
Melissa
checked by
WVG

not implemented - Bernardo Rudy - K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons. ext_link

input/validation/consistent
not implemented
evaluation criterion
The electrical models don't have genetically specified Kv1.1 current
id
49
species
mouse
age
P18-P40
brain region
BC
layer
ME-Type
fast spiking interneurons
aspect
Kv1.1
statement
Blocking Kv1.1 in AIS influence the delay firing type
pmid
18466749
title
K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons.
contact Name
Bernardo Rudy
contributed by
Werner
checked by
WVG

not implemented - Sacha B. Nelson - Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties. ext_link

input/validation/consistent
not implemented
evaluation criterion
The neocortical column model doesn't have clear distinction between projection types for the pyramidal cells
id
50
species
mouse
age
P23-28
brain region
S1
layer
5
ME-Type
PC
aspect
Layer 5 PC characterization
statement
Our findings indicate that corti-cothalamic and -trigeminal neurons are two largely nonoverlapping subpopulations, whereas callosal and corticostriatal neurons overlap extensively. The morphology as well as the intrinsic membrane and firing properties of corticothalamic and corticotrigeminal neurons differ from those of callosal and corticostriatal neurons. In addition, we find that each class of projection neuron exhibits a unique compliment of hyperpolarizing and depolarizing afterpotentials that further suggests that cortical neurons with different subcortical targets are distinct from one another.
pmid
17898147
title
Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties.
contact Name
Sacha B. Nelson
contributed by
J.Ryge
checked by
WVG

not implemented - Mel, BW - Location-dependent effects of inhibition on local spiking in pyramidal neuron dendrites. ext_link

input/validation/consistent
not implemented
evaluation criterion
The electrical models do not show indepedent dendritic spikes
id
51
species
rat
age
p20-p40
brain region
S1
layer
5
ME-Type
PC
aspect
dendritic spikes
statement
somatic inhibition divisively suppressed the amplitude of dendritic spikes recorded at the soma while minimally affecting dendritic spike thresholds
pmid
22719240
title
Location-dependent effects of inhibition on local spiking in pyramidal neuron dendrites.
contact Name
Mel, BW
contributed by
SR
checked by
WVG

not implemented - Staiger JF, Petersen CC - Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice. ext_link

input/validation/consistent
not implemented
evaluation criterion
The neocortical column model does not implement the quiet/active wakefullness state
id
52
species
mouse
age
brain region
Barrel cortex
layer
L2/3
ME-Type
inhibitory and excitatory neurons
aspect
synaptic interactions
statement
Fast-spiking GABAergic neurons dominate during quiet wakefulness, but during active wakefulness Non-fast-spiking GABAergic neurons depolarize, firing action potentials at increased rates
pmid
20159454
title
Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice.
contact Name
Staiger JF, Petersen CC
contributed by
Mirjia Herzog
checked by
WVG

not implemented - Andrea Lorincz and Zoltan Nusser - Molecular identity of dendritic voltage-gated sodium channels. ext_link

input/validation/consistent
not implemented
evaluation criterion
The electrical models don't contain Nav1.6, only currents marked as Transient Sodium current
id
53
species
rat
age
adult
brain region
hippocampus
layer
ME-Type
PC
aspect
dendritic voltage-gated Na+ (Nav) channels in AP-back propagation
statement
Using a highly sensitive electron microscopic immunogold technique, they revealed the presence of the Nav1.6 subunit in hippocampal CA1 PC proximal and distal dendrites. Here, the subunit density is lower by a factor of 35 to 80 than that found in axon initial segments. A gradual decrease in Nav1.6 density along the proximodistal axis of the dendritic tree was also detected without any labeling in dendritic spines. This paper show the characteristic subcellular distribution of the Nav1.6 subunit, identifying this molecule as a key substrate enabling dendritic excitability.
pmid
20466935
title
Molecular identity of dendritic voltage-gated sodium channels.
contact Name
Andrea Lorincz and Zoltan Nusser
contributed by
emmanuelle logette
checked by
WVG

not implemented - Mittman, T - Muscarinic inhibition of persistent Na+ current in rat neocortical pyramidal neurons. ext_link

input/validation/consistent
not implemented
evaluation criterion
Cholinergic innervation is currently not implemented
id
54
species
rat
age
p13-19
brain region
sensorimotor cx
layer
ME-Type
pyramidal neurons
aspect
muscainic modulation of persistent Na+ current
statement
I NaP of pyramidal cells can be modulated by the dense cholinergic innervation reaching the cerebral cortex. With the cholinergic agonist carbachol in combination with a nicotinic receptor antagonist, stimulation of muscarinic receptors causes an atropine-sensitive decrease of I NaP at all potentials without changing the voltage dependence of I NaP activation
pmid
9497434
title
Muscarinic inhibition of persistent Na+ current in rat neocortical pyramidal neurons.
contact Name
Mittman, T
contributed by
Melissa
checked by
WVG

not implemented - Rafael Lujan - Organisation of potassium channels on the neuronal surface. ext_link

input/validation/consistent
not implemented
evaluation criterion
Our electric models mostly contain pharmacolliogically specified current, this review mostly talks about genetically specified channels
id
55
species
rat
age
adult
brain region
CNS
layer
ME-Type
dendro-somato-axonic surface of the neurons
aspect
Ion channel localization in neurons
statement
review about organisation of potassium channel on the neuronal surface using many different techniques
pmid
20338235
title
Organisation of potassium channels on the neuronal surface.
contact Name
Rafael Lujan
contributed by
Emmanuelle Logette
checked by
WVG

not implemented - Robert C. Foehring - Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons. ext_link

input/validation/consistent
not implemented
evaluation criterion
The neocortical column model does not implement maturation
id
56
species
rat
age
P3 - P38
brain region
somatosensory cortex
layer
L2/3
ME-Type
acutely dissociated pyramidal neurons
aspect
Characterisation of the postnatal development of identified Kv channel-mediated currents
statement
Both the persistent/slowly inactivating and transient components of the total K+ current increased in density with postnatal age. We found that the density of all identified current components increased with postnatal age, approaching a plateau at 3-5 wk + The putative Kv2-mediated component was the largest at all ages. Immunocytochemistry indicated that protein expression for Kv4.2, Kv4.3, Kv1.4, and Kv2.1 increased between 1 wk and 4-5 wk of age + specific numbers in Tables 1-4 and figures throughout
pmid
21451062
title
Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons.
contact Name
Robert C. Foehring
contributed by
Oli
checked by
WVG

not implemented - Neil V Marrion - Rapid endocytosis provides restricted somatic expression of a K+ channel in central neurons. ext_link

input/validation/consistent
not implemented
evaluation criterion
The electrical neuron models do not explicitely model KCa 2.1, 2.2 and 2.3
id
57
species
rat
age
embryo
brain region
hippocampus
layer
ME-Type
cultured rat embryonic hippocampal neurons
aspect
KCa 2.1, 2.2, 2.3 trafficking in the soma of hippocampal neurons
statement
Identification of specific binding motifs being responsible for targeting to a particular subcellular location + role of intracellular transport proteins in soma localisation of KCa 2.1, 2.2 and 2.3 ion channels
pmid
19861491
title
Rapid endocytosis provides restricted somatic expression of a K+ channel in central neurons.
contact Name
Neil V Marrion
contributed by
emmanuelle logette
checked by
WVG

not implemented - Waters, J - Spiking patterns of neocortical L5 pyramidal neurons in vitro change with temperature. ext_link

input/validation/consistent
not implemented
evaluation criterion
The ion channel kinetics we use are for a fixed temperature. We can not test the firing pattern at different temperatures
id
58
species
mouse
age
adult
brain region
S1/M1
layer
L5
ME-Type
PC
aspect
AP firing rate
statement
The manner in which layer 5 pyramidal neurons translate synaptic input into an output spiking pattern is fundamentally altered at sub-physiological temperatures
pmid
21286222
title
Spiking patterns of neocortical L5 pyramidal neurons in vitro change with temperature.
contact Name
Waters, J
contributed by
SR
checked by
WVG

not implemented - Kole, MHP - State and location dependence of action potential metabolic cost in cortical pyramidal neurons. ext_link

input/validation/consistent
not implemented
evaluation criterion
The electrical models don't mechanism the measure the energy metabolism of the neurons
id
59
species
rat
age
adult
brain region
S1
layer
L5
ME-Type
PC
aspect
AP metabolic cost
statement
The high metabolic cost of action potential initiation and propagation down the axon is a trade-off between energy minimization and maximization of the conduction reliability of high-frequency action potentials.
pmid
22660478
title
State and location dependence of action potential metabolic cost in cortical pyramidal neurons.
contact Name
Kole, MHP
contributed by
SR
checked by
WVG

not implemented - Matthew Larkum - The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons. ext_link

input/validation/consistent
not implemented
evaluation criterion
These experiments are done in older animals. Our models don't have calcium dynamics in the dendrites
id
60
species
mouse
age
P27-35
brain region
S1
layer
5
ME-Type
pyramidal neurons
aspect
dendritic currents
statement
the mechanism underlying the GABAB inhibition of Ca2+ spikes involves direct blockade of dendritic Ca2+ channels.
pmid
16701210
title
The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons.
contact Name
Matthew Larkum
contributed by
Shruti
checked by
WVG

not implemented - Larkum ME - Top-down dendritic input increases the gain of layer 5 pyramidal neurons. ext_link

input/validation/consistent
not implemented
evaluation criterion
Calcium action potentials are currently not implemented in the pyramidal cell electrical models
id
61
species
rat
age
P26-43
brain region
neocortex
layer
L5
ME-Type
PC
aspect
I/O relationship PCs
statement
Noisy currents injected in ramps at different dendritic locations showed that the initial slope of the frequency-current (f/I) relationship increases with the distance of the current injection from the soma.
pmid
15115747
title
Top-down dendritic input increases the gain of layer 5 pyramidal neurons.
contact Name
Larkum ME
contributed by
Werner
checked by
WVG

not implemented - Sacha B Nelson - Transcriptional and electrophysiological maturation of neocortical fast-spiking GABAergic interneurons. ext_link

input/validation/consistent
not implemented
evaluation criterion
The neocortical column model does not implement maturation
id
62
species
mouse
age
P7, P10, P13-15, P25 and P40-45
brain region
somatosensory cortex
layer
layers 2/3, 5, and 6,
ME-Type
Fast spiking IN
aspect
Transcriptional and Electrophysiological Maturation of FS IN
statement
We found that the intrinsic and synaptic physiology of FS cells undergoes profound regulation over the first 4 postnatal weeks and that these changes are correlated with primarily monotonic but bidirectional transcriptional regulation of thousands of genes belonging to multiple functional classes. Using our microarray screen as a guide, we discovered that upregulation of two-pore K leak channels between P10 and P25 contributes to one of the major differences between the intrinsic membrane properties of immature and adult FS cells and found a number of other candidate genes that likely confer cell-type specificity on mature FS cells.
pmid
19474331
title
Transcriptional and electrophysiological maturation of neocortical fast-spiking GABAergic interneurons.
contact Name
Sacha B Nelson
contributed by
J.Ryge
checked by
WVG

not implemented - Gentet, L.J. - Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex ext_link

input/validation/consistent
not implemented
evaluation criterion
The paper is dependent on behavioral input, which is not implemented in the neocortical column model
id
63
species
mouse
age
-
brain region
primary somatosensory barrel cortex
layer
2,3
ME-Type
Neocortical GABAergic neurons
aspect
membrane potential dynamics
statement
SOM cells will hyperpolarize and reduce action potential firing whenever a given cortical area is actively involved in processing behaviorally relevant information.
pmid
22366760
title
Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex
contact Name
Gentet, L.J.
contributed by
John Fielden
checked by
WVG

not implemented - Benedicte Dargent - Voltage-gated sodium channel organization in neurons: protein interactions and trafficking pathways. ext_link

input/validation/consistent
not implemented
evaluation criterion
The electrical models don't contain Nodes of Ranvier
id
64
species
mouse
age
adult
brain region
CNS
layer
ME-Type
AIS and nodes of ranvier of neurons
aspect
Nav channels distribution and targeting in the AIS and the nodes of ranvier
statement
Review on Nav subtype localization and targeting in neurons and the possible interplay between electrogenesis properties and Nav concentration at the AIS and the nodes
pmid
20817077
title
Voltage-gated sodium channel organization in neurons: protein interactions and trafficking pathways.
contact Name
Benedicte Dargent
contributed by
Emmanuelle Logette
checked by
WVG

possibly consistent - Greg Stuart - Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
65
species
rat
age
P14-P35
brain region
S1
layer
L5
ME-Type
PC
aspect
Kv1 in AIS
statement
10-fold increase in Kv1 channel density over the first 50 μm of the AIS.
pmid
17698015
title
Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy.
contact Name
Greg Stuart
contributed by
Werner
checked by
WVG

possibly consistent - D. Ulrich - Dendrosomatic voltage and charge transfer in rat neocortical pyramidal cells in vitro. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
66
species
rat
age
P12 - P18
brain region
somatosensory cortex
layer
L5
ME-Type
Pyramidal neurons
aspect
Characterisation of dendrosomatic charge and voltage transfer
statement
We find that around rest, the dendrite behaves like a linear cable. The cutoff frequency for somatopetal current transfer is around 4 Hz, i.e., synaptic inputs are heavily low-pass filtered. We conclude that the integrative properties of dendrites in infragranular neocortical pyramidal cells appear to be linear near resting membrane potential. However, at polarized potentials charge transferred is voltage-dependent with a loss of charge at hyperpolarized and a gain of charge at depolarized potentials.
pmid
10980017
title
Dendrosomatic voltage and charge transfer in rat neocortical pyramidal cells in vitro.
contact Name
D. Ulrich
contributed by
Oli
checked by
WVG

possibly consistent - Costa M. Colbert - Ion channel properties underlying axonal action potential initiation in pyramidal neurons. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
67
species
rat
age
p14-24
brain region
neocortex
layer
L5
ME-Type
PC
aspect
Electrophysiological properties
statement
Na_t activation V1/2 shift between soma and axon
pmid
11992119
title
Ion channel properties underlying axonal action potential initiation in pyramidal neurons.
contact Name
Costa M. Colbert
contributed by
Etay Hay
checked by
WVG

possibly consistent - Nelson,SB - Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
68
species
mouse
age
p23-p28
brain region
S1
layer
L5
ME-Type
PC
aspect
Electrophysiological properties
statement
Each class of projection neuron exhibits a unique compliment of hyperpolarizing and depolarizing afterpotentials that further suggests that cortical neurons with different subcortical targets are distinct from one another.
pmid
17898147
title
Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties.
contact Name
Nelson,SB
contributed by
SR
checked by
WVG

possibly consistent - Zaitsev A V - P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
69
species
rat
age
p19-p22
brain region
medial prefrontal cortex
layer
2,3
ME-Type
fast spiking interneurons
aspect
AP
statement
fast, <=0.50ms at half-ampliture
pmid
17329622
title
P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex.
contact Name
Zaitsev A V
contributed by
Monica Favre
checked by
WVG

possibly consistent - Zaitsev A V - P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
70
species
rat
age
p19-p22
brain region
medial prefrontal cortex
layer
2,3
ME-Type
fast spiking interneurons
aspect
after hyperpolarization
statement
deep monophasic, 22.5 ± 0.8mV
pmid
17329622
title
P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex.
contact Name
Zaitsev A V
contributed by
Monica Favre
checked by
WVG

possibly consistent - Zaitsev A V - P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
71
species
rat
age
p19-p22
brain region
medial prefrontal cortex
layer
2,3
ME-Type
fast spiking interneurons
aspect
input resistance
statement
low, 212 ± 10Mohms
pmid
17329622
title
P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex.
contact Name
Zaitsev A V
contributed by
Monica Favre
checked by
WVG

possibly consistent - Zaitsev A V - P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
72
species
rat
age
p19-p22
brain region
medial prefrontal cortex
layer
2,3
ME-Type
fast spiking interneurons
aspect
membrane time constant
statement
fast, 7.8 ± 0.9ms
pmid
17329622
title
P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex.
contact Name
Zaitsev A V
contributed by
Monica Favre
checked by
WVG

possibly consistent - Zaitsev A V - P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
73
species
rat
age
p19-p22
brain region
medial prefrontal cortex
layer
2,3
ME-Type
pyramidal cells
aspect
AP, hyperpolarization, input resistance membrane time constant
statement
values not described, but plotted Figure 1
pmid
17329622
title
P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex.
contact Name
Zaitsev A V
contributed by
Monica Favre
checked by
WVG

possibly consistent - Karpuk N, Vorobyov V. - Spike sequences and mean firing rate in rat neocortical neurons in vitro. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
74
species
rat
age
adult
brain region
neocortex
layer
layers II/III and V
ME-Type
pyramidal neurons
aspect
neuronal discharges and their interrelationship with mean evoked firing rate (MF)
statement
single neurons display parameters within a limited range of electrophysiological properties whereas neuronal populations exhibit the continuum of properties (e.g. the AHP shapes
pmid
12729949
title
Spike sequences and mean firing rate in rat neocortical neurons in vitro.
contact Name
Karpuk N, Vorobyov V.
contributed by
Mirjia Herzog
checked by
WVG

possibly consistent - Korngreen, A - Subthreshold inactivation of voltage-gated K+ channels modulates action potentials in neocortical bitufted interneurones from rats. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
75
species
rat
age
p13-p15
brain region
S1
layer
L5
ME-Type
BTC
aspect
K+ channels
statement
The study investigated the role of voltage-gated channels in the modulation of AP waveform in bitufted interneurones. We show that subthreshold depolarization induces inactivation of voltage-gated K+ conductance resulting in broadening of somatic APs. Dendritic whole-cell and Ca2+-imaging experiments suggest that the broadening of the somatic AP is echoed by changes in the b-AP inducing a larger dendritic Ca2+ influx.
pmid
15539396
title
Subthreshold inactivation of voltage-gated K+ channels modulates action potentials in neocortical bitufted interneurones from rats.
contact Name
Korngreen, A
contributed by
SR
checked by
WVG

possibly consistent - D. Zecevic - The spatio-temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging study. ext_link

input/validation/consistent
possibly consistent
evaluation criterion
id
76
species
mouse
age
P5-P9 and P15-P30
brain region
SSC
layer
L5
ME-Type
PC
aspect
AIS APs
statement
Time course of action potentials in AIS and soma
pmid
21669974
title
The spatio-temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging study.
contact Name
D. Zecevic
contributed by
Werner
checked by
WVG