Metabolism

Experimental data

Illustration for Metabolism experimental data

Metabolism

Experimental data

The experimental data including concentrations of molecules and kinetic parameters and equations for enzymatic rate equations were manually collected from a large number of publications and databases (sources are listed in the references of the metabolism paper).

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Initial values of variables

The molecules of the brain, and in particular, metabolites, are important players of all the biochemical pathways that underlie the neuronal function. The molar concentrations are commonly used as a quantitative measure in modeling and simulation studies. This data was carefully collected from all the available resources, taking into account conditions and metadata when it was provided. In some cases, the approximations were made given the lack of data or contradictory reports coming from different sources.

System of differential equations for coupled simulation of metabolism, electrophysiology and blood flow

Model is implemented as a system of differential equations given below.